JunB (pS79)
Jun B proto-oncogene; AP-1
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Antigen Preparation
A synthetic peptide of human JunB with a phosphrylation site Serine 79
Background
"Jun-B is a member of the activator protein-1 (AP-1) transcription factor family that has been implicated in a multitude of physiologic processes and tumorigenesis. Jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It not only inhibits but also enhances the transcription of c-Jun targets in combination with c-Jun. For example, JunB can enhance the transcription of IL-8 in oral squamous cell carcinoma. JunB is also essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment"
PURIFICATION
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
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SPECIFICITY
This antibody recognizes JunB with the phosphorylation site Serine 79. It does not cross-react with non-phosphospecific peptide.
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FORMULATION
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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