4E-BP1

Product Preparation
Background
4E-BP1 eukaryotic initiation factor 4E binding protein 1 is a member of a family of translation repressor proteins. It inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. In the unphosphorylated form, it suppresses the translation initiation of capped mRNAs, whereas in phosphorylated form, it increases translation initiation. Several kinases phosphorylate 4E-BP1 dependent or independent of mTOR, indicating that mTOR may not be the only kinase that phosphorylates 4E-BP1. It is a multi-functional protein, in addition to translation repression, under certain cellular conditions it may also play a role as a tumor promoter. The protein is involved in tumorigenesis and is overexpressed in various carcinomas.
PURIFICATION
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
SPECIFICITY
FORMULATION
STORAGE
Gene ID
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 604-010
Lot #:
Size: 100 ug
Host: Mouse
Clone: 554R16
Isotyping: IgG1
Applications: WB; IHC
Reactivity: Hu, Ms
Price: $ 245.00
REFERENCES
Soudais C, et al. (1993).. Nature Genetics. 3 (1): 77–81 Wong S, et al. (1991). . Clinical and Experimental Immunology. 83 (1): 69–73 Gagnon E, et al. (2012)J Exp Med. 2012 Dec 17;209(13):2423-39
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