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Antigen Preparation
A recombinant protein of full length human 4E-BP1
"4E-BP1 eukaryotic initiation factor 4E binding protein 1 is a member of a family of translation repressor proteins. It inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. In the unphosphorylated form, it suppresses the translation initiation of capped mRNAs, whereas in phosphorylated form, it increases translation initiation. Several kinases phosphorylate 4E-BP1 dependent or independent of mTOR, indicating that mTOR may not be the only kinase that phosphorylates 4E-BP1. It is a multi-functional protein, in addition to translation repression, under certain cellular conditions it may also play a role as a tumor promoter. The protein is involved in tumorigenesis and is overexpressed in various carcinomas."
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
This antibody recognizes human 4E-BP1 protein. The other species are not tested.
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
0.01-0.1 µg/ml
2-5 µg/ml
2-10 µg/ml
Flow cytometry
Not tested
Order Info
Catalog #: 604-010
Lot #:
Size: 100ug/200ul
Host: Mouse
Clone: 554R16
Isotyping: IgG1
Applications: IHC(P), WB
Reactivity: Hu, Ms
Price: $ 245.00
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