15-Lox-2
15-Lipoxygenase 2

PDF Image Download Product PDF PDF Image MSDS Download Product PDF
Product Preparation
N/A
Background
15-LOX-2 is a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. This catalyzes the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13. 15-lipoxygenases (15-LOXs) have been implicated in various macrophage functions including efferocytosis and ferroptosis. It plays an important role in cholesterol homeostasis and CCL17 production in human macrophages.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
N/A
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 600-590
Lot #: See the label
Size: 100 ug
Host: Rabbit
Clone:
Isotyping: Rabbit IgG
Applications: WB, ELISA
Reactivity: Hu
Price: $ 219.00
REFERENCES
Jisaka M, Kim RB, Boeglin WE and Brash AR. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. J. Biol. Chem. 275 (2), 1287-1293 (2000)
©2011-2025 Abbomax.com. All rights reserved.