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Katanin, P80

Katanin P80

Antigen Preparation

A Human B cell nuclei from plasmacytoid 2p68 cells

Background

The Ku autoantigen is a heterodimer of 70kDa (p70) and ~80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase that phosphorylates certain ranscription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis. This antibody recognizes p70/p80 dimer which is destroyed during Western Blot.

PURIFICATION The antibody is purified from Ascites fluid by Protein G	SPECIFICITY
FORMULATION This affinity purified antibody is supplied in sterile Phosphate-buffered saline (pH7.2) containing antibody stabilizer.	STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC to –70oC

Gene ID

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

N/A

Immunoprecipitation

1-5 µg/ml

IHC

1:50

Flow cytometry

N/A

Order Info

Catalog #:	500-6004
Lot #:	See the label
Size:	100ug
Host:	Mouse
Clone:
Isotyping:
Applications:	IHC(P); IP; IF
Reactivity:	Human
Price:	$ 299.00

REFERENCES