14-3-3 zeta
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

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Antigen Preparation
A synthetic peptide corresponding to the internal sequence (134-149aa) of human 14-3-3 zeta.
"The 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14.3.3 zeta protein is a ubiquitous and abundant in brain. 14.3.3 zeta binds primarily to Raf noncatalytic sequences without inhibiting the Ras-Raf association or Raf-catalyzed MEK phosphorylation, thus it might act as a sweeper of misfolded protein by facilitating the formation of aggregates (inclusion bodies). Hence, 14-3-3 zeta may be considered as an auxiliary therapeutic tool in the protein aggregation disorders."
The Rabbit IgG is purified by Epitope Affinity Purification
"This antibody recognizes ~30 kDa of human 14.3.3 zeta protein. This antibody reacts with human, mouse and rat. The other species are not tested."
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
0.01-0.1 µg/ml
2-5 µg/ml
2-10 µg/ml
Flow cytometry
Not tested
Order Info
Catalog #: 500-12604
Lot #: See the label
Size: 100ug/200ul
Host: Rabbit
Isotyping: Rabbit IgG
Applications: IHC-P, WB
Reactivity: Hu, Ms, Rt
Price: $ 189.00
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