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STAT6 (pY641)

Signal transducer and activator of transcription 6 (STAT6)

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Antigen Preparation

"A synthetic peptide surrounding to the epitope -RGYVP-- with phosphorylation sites at Tyr641 of STAT6 protein from human, mouse and rat origins."

Background

"STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a ligand binding to its cell surface receptor. Activation by phosphorylation of STAT6 at tyrosine 641 upon the IL-4 (possibly IL-13) ligand binding to its receptor induces dimerization, nuclear translocation and DNA binding. STAT6 is widely expressed in human tissues. It exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. STAT6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity"

PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification.	SPECIFICITY This antibody recognizes STAT6 (pY641) with a phosphorylated sites of Tyr641. It does not cross-react with non-phosphospecific peptide.
FORMULATION This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer	STORAGE The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Gene ID

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5 µg/ml

IHC

2-10 µg/ml

Flow cytometry

Not tested

Order Info

Catalog #:	500-12104
Lot #:	See the label
Size:	100ug/200ul
Host:	Rabbit
Clone:
Isotyping:	Rabbit IgG
Applications:	IHC(P), WB, IP
Reactivity:	Hu, Ms
Price:	$ 245.00

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