Calretinin
CALB2, Calretinin, Calbindin2
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Antigen Preparation
"A synthetic peptide of internal segment of human calretinin protein. It is identical among human, mice and rat species."
Background
"Calretinin is an intracellular calcium-binding protein that belongs to the troponin C superfamily. It has cellular functions including intracellular calcium buffering, messenger targeting, and is involved in processes such as cell cycle arrest, and apoptosis. Calretinin belongs to the so-called EF-hand family of calcium binding proteins. The EF-hand is an evolutionary well preserved amino acid domain with a characteristic threedimensional structure and with a high affinity for calcium ions. Calretinin is composed of 269-271 amino acid residues and contains six EF-hand domains. The mammalian neuronal cytoplasmic concentration of calretinin was estimated to be in order of tens of micromoles."
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
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SPECIFICITY
"This antibody reacts with Calretinin. It cross reacts to human, mice and rat."
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FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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