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CD45/LCA

CD45 Leucocyte common antigen (LCA)

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Antigen Preparation

Recombinant protein encoding aa 1119-1304 of human CD45.

Background

"CD45 leucocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals. CD45 plays an essential role in lymphocyte activation. "

PURIFICATION The Rabbit IgG is purified by Epitope Affinity Purification	SPECIFICITY This antibody reacts with human CD45. The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer	STORAGE The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Gene ID

5788

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

N/A

Immunoprecipitation

N/A

IHC

2-10 µg/ml

Flow cytometry

Not tested

Order Info

Catalog #:	500-10564
Lot #:	See the label
Size:	100ug/200ul
Host:	Rabbit
Clone:
Isotyping:	Rabbit IgG
Applications:	WB
Reactivity:	Hu
Price:	$ 245.00

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