Annexin IV
ANXA4, ANX4, PIG28, ZAP36
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Antigen Preparation
"A synthetic peptide corresponding to the N-terminus of human Annexin IV. This sequence is identical to human, mouse and rat."
Background
"The annexins are a family of highly homologous Calcium and phospholipid binding proteins. It is composed of at least ten mammalian genes. It is characterized by a conserved core domain which binds to phospholipids in a Ca2+ dependent manner and a unique amino terminal region which may confer binding specificity. Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis/exocytosis and cellular adhesion, Annexin IV, also referred to as endonexin, functions to regulate Cl—flux by mediating calmodulin kinase II (CaMKII) activity while Annexin V has been shown to regulate PKC activity. The expressive amounts of several annexins have been shown to alter in certain pathological states such as brain ischemia and Alzheimer's disease."
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
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SPECIFICITY
"This antibody recognizes Annexin IV protein. It cross-reacts to human, mouse and rat. Others are not tested."
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FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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