CCZ1

PDF Image Download Product PDF
Product Preparation
A synthetic peptide derived from a portion of the intra domain 350-395aa of human CCZ1 protein. This sequence is identical to human, mouse, rat, bovine and chicken.
Background
SAND-1 (Mon1a (490aa) and Mon1b (547aa)) and CCZ-1 (Ccz1) are new factors for the apoptotic cells removal. Impaired apoptotic cell clearance (due to defective recognition, internalization or degradation) results in autoimmune disease. Mon1a and Mon1b, are similarly required for phagosome maturation. Mon1a and Mon1b are required for phagosome maturation. Mona and its partner CCZ-1 form a complex (but not either protein alone) could bind small GTPase Rab7, thus influence Rab7 activation; Mon1a, Mon1b and CCZ-1 are critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody recognizes ~55 kDa of CCZ1 protein. It cross-reacts to human, mouse and rat origins. The other species are not tested.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
N/A
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 630-160
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: ELISA, WB
Reactivity: Hu, Ms,
Price: $ 245.00
REFERENCES
Kinchen,J.M. and Ravichandran,K.S. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Nature 464 (7289), 778-782 (2010)
©2011-2015 Abbomax.com. All rights reserved.