Antigen Preparation
A synthetic peptide containing the epitope IS GIC-S*-PL with a phosphorylation site at Serine 1124 of human LRRK2. This sequence is also identical within human, rat and mouse.
Background
"LRRK2, leucine rich repeat kinase 2, belong to the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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