PLAC1(pY147)
placenta-specific 1

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Product Preparation
A synthetic peptide corresponding to the phosphorylation site at Tyrosine 147 surrounding the epitope -EKCYEVF- of human Placenta-specific 1 protein. This sequence is derived from human origin.
Background
The PLAC1, a placenta-specific gene, which encodes a putative cell surface protein, is highly expressed in placenta, testis, and wide range of human malignancies, most frequently in breast cancer, and essentially involved in cancer cells proliferation, migration and invasion. The activation of PLAC1 is selectively controlled by ubiquitous transcription factor SP1 and positively correlated between PLAC1 and ER-alpha in breast cancer. PLAC1 is also expressed in human hepatocellular cancer tissues as well as in several other types of cancer tissues and/or tumor cell lines. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination.
PURIFICATION
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
SPECIFICITY
This antibody recognizes ~22 kDa of PLAC1 protein at a phosphorylation site of Tyrosine 147. It cross-reacts to human, not the other species.
FORMULATION
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
10761
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 620-400
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: ELISA, WB, IHC
Reactivity: Hu,
Price: $ 365.00
REFERENCES
Dong XY, et al. Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients. Int J Cancer. 122(9):2038-43 (2008).
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