CCR9
CCR9, CCR9A, CCR9B, CDw199
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Antigen Preparation
A synthetic peptide derived from N-terminus of the extracellular domain of human CCR9 protein.
Background
"CCR9, or C-C Motif Chemokine receptor type 9, is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been found on lymphoid cells in both constitutively and in inflammation. It occurs on T lymphocytes of the small intestine, thymus, lymph node and spleen. CCR9 has mainly been reported to function in lymphocyte migration although other cell types, such as tumor cells, can express CCR9, playing a role in prostate cancer cell migration and invasion."
PURIFICATION
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
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SPECIFICITY
This antibody recognizes human CCR9 protein. The other species are not tested.
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FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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