BCL-w
BCL2-like 2;BCL2L2; BCL-w, BCLW

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Product Preparation
A synthetic peptide derived from N-terminus of human BCL-W protein. This sequence is identical among human, rat and mouse origins.
Background
BCL-w is a member of the Bcl-2 family. The gene codes for a 21 kDa protein which is essential for the regulation of cellular survival, and that is up-regulated in different human tumors, such as gastric and colorectal carcinomas. Inhibition of AKT activity may promote apoptosis through the down-regulation of Bcl-w protein and the consequential reduction in interaction of Bcl-w with pro-apoptotic members of the Bcl-2 family.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
BCL-w is a member of the Bcl-2 family. The gene codes for a 21 kDa protein which is essential for the regulation of cellular survival, and that is up-regulated in different human tumors, such as gastric and colorectal carcinomas. Inhibition of AKT activity may promote apoptosis through the down-regulation of Bcl-w protein and the consequential reduction in interaction of Bcl-w with pro-apoptotic members of the Bcl-2 family.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
599
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 602-950
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: ELISA, WB, IHC
Reactivity: Hu, Ms, Rt, Ck, Bv, Canis
Price: $ 295.00
REFERENCES
Gibson,L., Bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene 13 (4), 665-675 (1996)
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