B-cell lymphoma protein 2, (alpha isoforms), BCL2,

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Product Preparation
A synthetic peptide derived from internal sequence (40-55aa) of human BCL-2 oncoprotein.
The Bcl-2 gene codes for a 26 kDa protein which has been implicated in the control of cell death by apoptosis, in normal tissues, expression of bcl-2 is restricted to cells and tissues that are characterized by apoptotic cell turnover. Bcl-2 protein exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release, thus it is also considered as an inner mitochondrial membrane protein which can be expressed in lymphoma and breast carcinoma cells. This protein modulates mitochondrial calcium homeostasis and proton flux. BCL-2 protein is frequently overexpressed in many lymphoid malignancies, thus it can immunohistologically distinguish neoplastic germinal centers from reactive ones.
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
This antibody recognizes human Bcl-2 oncoprotein only.
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
0.01-0.1 µg/ml
2-5 µg/ml
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 500-1124
Lot #: See the label
Size: 100 ug
Host: Mouse
Isotyping: Mouse IgG1
Applications: IHC(P), WB, IP, IF, FC
Reactivity: Hu
Price: $ 269.00
Camlica H., et al. Statistical interpretation of CA125 and Bcl-2 in serum of patients with late stage ovarian cancer. Am J Clin Oncol, 2008 Dec, 31(6): 585-8.
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