CD20
MS4A1, CD20, CD20 antigen, CD20 receptor, B-Lympho

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Product Preparation
A synthetic peptide corresponding to C-terminus of human CD20 protein.
Background
CD20, a non-glycosylated protein, belongs to a member of the membrane-spanning 4A gene family. The molecular weight is at a range of ~34-37kDa depending on the degree of the protein phosphorylation. The CD20 antigen is present on human pre B lymphocytes and B lymphocytes at all stages of maturation. Thus, it plays an important role in the development and differentiation of B-cells into plasma cells. Low level of CD20 expression appears on normal T lymphocytes. Combination of chemo and humanized CD20 antibodies has been reported in clinical study of lymphoma diseases.
PURIFICATION
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
SPECIFICITY
This antibody recognizes ~34 kDa of human CD20. The other species are not tested
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
931
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 500-11214
Lot #: See the label
Size: 100 ug
Host: Mouse
Isotyping: Mouse IgG2a
Applications: IHC-P
Reactivity: Hu
Price: $ 349.00
REFERENCES
Smith MR, Rituximab (monoclonal anti-CD20 antibody: mechanisms of action and resistance. Oncogene, 2003 Oct 20;22(47):7359-68.
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