Calumenin
CALU;

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Product Preparation
A synthetic peptide corresponding to the N-terminus of Calumenin protein. This sequence is identical to rat, mouse and human origins.
Background
Calumenin (CALU) is a calcium binding protein localized in the endo/sarcoplasmic reticulum (ER) in mammalian tissues. It is involved ER and Golgi apparatus named CERC which is an acronym for its family members Cab-45, reticulocalbin, Erc-55 and Calumenin. The CALU gene encodes a deduced 315aa protein containing six- EF-hand Ca2+-binding protein with one potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse/rat CALU proteins are 98% identical. Two isoforms exist in cardiac and skeletal muscles, but Calumenin-2 is the main isoforms in skeletal muscle. Increasing in the expression of Calumenin in chemotherapeutic drug resistance in neoplastic cells is observed. It is also involved in the pathophysiology of thrombosis or in wound healing. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody recognizes ~48 kDa of Calumenin Protein. It cross reacts with human, mouse and rat. The other species are not tested.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
813
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 600-640
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: WB, ELISA
Reactivity: Hu, Ms, Rt
Price: $ 255.00
REFERENCES
Yabe,D., et al. Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. J. Biol. Chem. 272 (29), 18232-18239 (1997)
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