BCAR3
breast cancer anti-estrogen resistance 3

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Product Preparation
A synthetic peptide derived from C-terminus of human BCAR3 protein. This sequence is identical to human, rat, mouse, canis and bovine.
Background
Breast cancer anti-estrogen resistance 3 (BCAR3) is a also known as AND-34/BCAR3/NSP2 (BCAR3). Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. BCAR3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48
PURIFICATION
N/A
SPECIFICITY
This antibody recognizes human BCAR3 protein. It cross reacts to human, mouse and rat. The other species was not tested.
FORMULATION
N/A
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
8412
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 600-100
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: WB, IHC
Reactivity: Hu, Rt, Ms
Price: $ 265.00
REFERENCES
Makkinje,A., et al. AND-34/BCAR3 regulates adhesion-dependent p130cas serine phosphorylation and breast cancer cell growth pattern. Cell. Signal. 21 (9), 1423-1435 (2009).
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