Blk
B lymphoid tyrosine kinase

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Product Preparation
A synthetic peptide corresponding to N-term of human Blk protein. This sequence is identical to mouse and rat.
Background
The Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transducer signals that are involved in the control of a variety of cellular process, including proliferation, differentiation, motility, and adhesion. Blk is a 505 aa protein, known as a nonreceptor tyrosine-kinase of the Src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucos and enhances the expression of several pancreatic beta-cell transcription factors. Blk protein is expressed exclusively by B lymphocytes.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody reacts with human Caspase-10. The other species are not tested.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
640
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 500-10904
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: WB
Reactivity: Hu
Price: $ 349.00
REFERENCES
Vlam,L., Cats,E.A., Seelen,M., van Vught,P.W., van den Berg,L.H. and van der Pol,W.L. Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes. J. Peripher. Nerv. Syst. 16 (3), 175-179 (2011).
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