SARS-CoV-2 (N)
SARS-COV-2 N (nucleocapsid) protein

Product Preparation
A synthetic peptide derived from C-terminus of SARS-COV-2 N (nucleocapsid) protein
Background
The SARS-CoV-2 nucleocapsid (N) is a 45 kDa protein, one of the major structural proteins of the virus. It binds directly to viral RNA and provides stability. N-protein is involved in the transcription and viral RNA replication, packaging of the encapsidated genome into helical ribonucleocapsid, and interference with cell cycle processes of host cells. This most abundant protein of coronavirus is composed of two structural domains and a linker region. N-protein contains two independent RNA binding domains, the N-terminal RNA binding domain and a C-terminal domain, which can interact with the viral RNA to form the ribonucleoprotein. The linker region binds to the M protein. The N-protein is a highly immunogenic phosphoprotein and is extremely conserved. This protein is a repressor of RNA interference and an antagonist of interferon.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody recognizes ~SARS-CoV-2 protein. This antibody has been tested in human infected tissues
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three-month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-1 µg/ml
Immunoprecipitation
N/A
IHC
1:100
Flow cytometry
N/A
Order Info
Catalog #: 630-940
Lot #: 172
Size: 100 ug
Host: Rabbit
Isotyping: IgG
Applications: ELISA, WB, IHC(P)
Reactivity: SARS-CoV-2
Price: $ 245.00
REFERENCES
F. K. Yoshimoto Protein J. 2020; 39(3): 198–216. Liu, W. et al. J. Clin. Microbiol. 2020 doi: 10.1128/JCM.00461-20. J. Wu, et al. Front Microbiol. 2020; 11: 1576. Published online 2020 Jul 3
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