c-fos
p55; c-FOS; AP-1

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Product Preparation
A synthetic peptide corresponding to N-term of c-Fos protein. This sequence is identical in human, mouse, rat abd bovine.
Background
The c-Fos proto-oncogene, an 55 kDa nuclear phosphor-protein, belongs to a family of transcription factors. It plays important roles in cell proliferation and differentiation. c-Fos is associated with the c-Jun protein, forming a stable c-Fos/c-Jun heterodimeric complex, this complex binds to the DNA promoter region which regulate transcription. Expression of the c-Fos gene is low in most normal adult tissues. However, high levels of expression have been detected in normal skin.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody recognizes c-Fos protein. It cross-reacts to human, mouse, rat. The other species were not tested.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
N/A
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5 µg/ml
IHC
2-10 µg/ml
Flow cytometry
5-10 µg/ml
Order Info
Catalog #: 500-4464
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: IHC(P)
Reactivity: Hu, Rt, Ms
Price: $ 280.00
REFERENCES
Wang,Z.Q., Ovitt,C., Grigoriadis,A.E., Mohle-Steinlein,U., Ruther,U. and Wagner,E.F. Bone and haematopoietic defects in mice lacking c-fos. Nature 360 (6406), 741-745 (1992).
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