CD147/EMMPRIN
CD147; EMMPRIN;

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Product Preparation
Recombinant protein of full length of human CD147.
Background
CD147 or EMMPRIN (extracellular matrix metalloproteinase inducer) is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. This protein is also a member of the immunoglobulin super-family, it is a 58kDa protein with two immunoglobulin domains that was originally purified from the plasma membrane of the human LX-1 lung carcinoma cell line. CD147 has been localized on the outer surface of tumor cells, where it interacts withfibroblasts to stimulate the expression of matrix metalloproteinases (MMPs). CD147 inhibition has been proposed as a novel strategy in the prevention of cancer invasion and metastasis.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody reacts with human. The other species are not tested.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
682
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
N/A
Immunoprecipitation
N/A
IHC
2-10 µg/ml
Flow cytometry
Not tested
Order Info
Catalog #: 500-10534
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: WB
Reactivity: Hu
Price: $ 349.00
REFERENCES
Sidhu,S.S., Nawroth,R., Retz,M., Lemjabbar-Alaoui,H., Dasari,V. and Basbaum,C. EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis Oncogene 29 (29), 4145-4156 (2010)
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