CD10
CD10 antigen; CALLA; NEP; SFE

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Product Preparation
Synthetic peptide corresponding to internal region of human CD10
Background
CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is a 100-kDa type II transmembrane glycoprotein enzyme with neutral metalloendopeptidase activity which cleaves a variety of biologically active peptides hormones including glucagon, enkephalins, sybstance P, neurotensin, oxytocin and bradykinin. CD10 is largely expressed in ALL of lymphoblastic, Burkitt’s, and follicular germinal center lymphomas, as well as on CML of the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. However, it is also found on a variety of normal tissues, such as breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is present on leukemic cell of pre-B phenotype, which represenst 85% of cases of acute lymphocytic leukemia (ALL), thus it is an important cell surface marker in the diagnosis of human ALL.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody reacts with human. The other species are not tested.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Gene ID
4311
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
N/A
Immunoprecipitation
N/A
IHC
2-10 µg/ml
Flow cytometry
Not tested
Order Info
Catalog #: 500-10454
Lot #: See the label
Size: 100 ug
Host: Rabbit
Isotyping: Rabbit IgG
Applications: WB
Reactivity: Hu
Price: $ 349.00
REFERENCES
Malfroy,B., Kuang,W.J., Seeburg,P.H., Mason,A.J. and Schofield,P.R. Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase). FEBS Lett. 229 (1), 206-210 (1988)
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